Author

Marina Barrueco

University of Bath

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Ella Sawtell· 2 shared Maisem LaabeiiD· 2 shared Scott LovelliD· 2 shared Christopher WilliamsiD· 1 shared Ellie Hyde· 1 shared Jack MillsiD· 1 shared Jonathan WhitesideiD· 1 shared Marianne EngetiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

Ella Sawtell

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Expanding Macrocyclic Topology through Cysteine-to-N-Terminal Cyclisation Enables Covalent Peptide Inhibitor Discovery

Ella Sawtell, Marina Barrueco, Jonathan Whiteside, Christopher Williams, Maisem Laabei, Scott Lovell

This paper introduces a new cyclisation strategy using a bromomethyl picolinaldehyde linker to expand macrocyclic peptide topologies, leading to more potent and diverse inhibitors.

bioRxiv · Sep 8, 2026 · PreprintBiochemistry

Beyond the Catalytic Serine: Selective Protease Engagement with Covalent Macrocyclic Activity-based Probes

Marina Barrueco, Ellie Hyde, Ella Sawtell, Jack Mills, Vaia Nikoloudi, Marianne Enget, Maisem Laabei, Markus Lakemeyer, Scott Lovell

This paper introduces covalent macrocyclic activity-based probes (cmABPs) that selectively target non-catalytic residues in serine proteases, demonstrating their effectiveness with plasma kallikrein and urokinase plasminogen activator.

Chemical Science · Jan 1, 2026Peer-reviewedBiochemistry