BiochemistryChemical SciencePeer-reviewed
Beyond the Catalytic Serine: Selective Protease Engagement with Covalent Macrocyclic Activity-based Probes
Marina Barrueco, Ellie Hyde, Ella Sawtell…·Scott Lovell
This paper introduces covalent macrocyclic activity-based probes (cmABPs) that selectively target non-catalytic residues in serine proteases, demonstrating their effectiveness with plasma kallikrein and urokinase plasminogen activator.
DOI 10.1039/d6sc04245g