Linear ubiquitin chain assembly complex contributes to NLRP3-mediated pyroptotic cell death
Tiphaine Douanne, Rosalie Moreau, Valeria Trapani, Kilian Trillet, Hubert B. Leloup, Virginie Pétrilli, Julie Gavard, Nicolas Bidère
This study shows that linear ubiquitination, mediated by LUBAC, is essential for the execution phase of NLRP3-mediated pyroptosis, independent of priming.
iScience · Jun 17, 2026Peer-reviewedImmunology