Hubert B. Leloup

This study shows that linear ubiquitination, mediated by LUBAC, is essential for the execution phase of NLRP3-mediated pyroptosis, independent of priming.

This study identifies CRY-NLRP3 complexes as a circadian checkpoint that modulates inflammasome activation and drug response, showing time-of-day effects on inflammation and drug efficacy.

This study shows that pore-size dynamics in pyroptosis control cell swelling through GSDMD and Ninj1, with distinct permeability regimes affecting ion selectivity and water filtration.

This study shows membrane tension drives NINJ1 filament opening, causing cell lysis, and explains why NINJ2 fails to form lesions.