SUN2 mediates epigenetic remodeling to drive mechanotransduction during skin fibrosis
Aya Nassereddine, Kerri A. Davidson, Sandra Sandria, Jyot D. Antani, Shreyasi Das, Rachel Rivera, Van Anh Tran, Monique Hinchcliff, Megan C. King, Valerie Horsley
This study identifies SUN2 as a mediator of nuclear mechanosensing in fibrosis, showing it drives chromatin remodeling and fibrotic gene expression in response to mechanical stiffness.
bioRxiv · Mar 20, 2026 · PreprintCell Biology