Cholinergic synaptic plasticity shapes resilience and vulnerability to tau
Kate M. Onuska, Hayley R.C. Shanks, Lauren A. Devito, Qi Qi, Alycia M Crooks, Liliana Germán-Castelán, Geoffrey N. Ngo, Roy A.M. Haast, Tallulah S. Andrews, Kayla M. Williams, Flávio H. Beraldo, Ting Qiu, Alfonso Fajardo-Valdez, Jordana Remz, Alfie Wearn, , Taylor W. Schmitz
The paper shows that cholinergic synaptic plasticity, specifically VAChT responses to tau, correlates with cognitive resilience in presymptomatic AD.
bioRxiv · May 27, 2025 · PreprintNeuroscience