Set mediates chromosome alignment and Cohesin cleavage independently of direct PP2A-B56-binding in oocyte meiosis
Leonor Keating, Arianna Esposito-Verza, Warif El Yakoubi, Yulia Gryaznova, Safia El Jailani, Damien Cladière, Sandra A. Touati, Eulalie Buffin, Christophe Rachez, Varvara Sarli, Alberto M. Pendás, Wei Gu, Andrea Musacchio, Katja Wassmann
This study shows Set is essential for chromosome alignment and Cohesin cleavage in oocyte meiosis, functioning through Aurora B regulation and chromatin environment modulation, independent of PP2A-B56 interaction.
bioRxiv · Aug 21, 2026 · PreprintCell Biology