Andrea Musacchio

This study shows Set is essential for chromosome alignment and Cohesin cleavage in oocyte meiosis, functioning through Aurora B regulation and chromatin environment modulation, independent of PP2A-B56 interaction.

The paper identifies a high-affinity master docking motif on CENP-U that interacts extensively with PLK1's Polo-box domain, suggesting common features among master PLK1 docking motifs.

This study identifies the molecular mechanisms by which Ndc80 and Ska complexes cooperate to form stable kinetochore-microtubule attachments through structural and functional analyses.

This study identifies a non-centromeric role for CENP-B in binding hairpin motifs in chromosome arms, leading to dysregulated gene expression upon depletion.

The paper identifies proto-point centromeres in Saccharomycodales yeast, showing they evolved from retrotransposon LTRs, supporting the hypothesis that point centromeres originated from ancestral retrotransposons.

The paper identifies M18BP1 dimerization and its interaction determinants as key for centromere specification through epigenetic mechanisms in humans.

This study identifies Bora as essential for Aurora A-mediated phosphorylation of PLK1's Thr210, revealing a unique interaction required for this process.

This study shows POLO kinase phosphorylates PP187B to inhibit its interaction with MPS1, maintaining SAC activity and preventing aneuploidy during mitosis.

The paper identifies M18BP1 as a factor required for condensin II localization to chromatin and shows it competes with MCPH1 to activate condensin II during mitosis.

This study identifies two non-redundant pathways for kinetochore corona assembly involving BUB1 and BUBR1, revealing their roles in chromosome biorientation and checkpoint signaling.

The paper investigates how kinetochores facilitate the rapid assembly of the mitotic checkpoint complex (MCC) by co-orienting SAC catalysts in vitro.

This study identifies multiple CCAN binding sites and shows that FACT localization to kinetochores depends on specific CCAN subcomplexes and is regulated by CK2 phosphorylation and DNA displacement.

The paper identifies a phosphorylation network regulated by PLK1 that controls a conformational switch necessary for CENP-A deposition, essential for centromere maintenance.

The paper presents a structural and functional analysis of the KMN network, revealing key interfaces and their role in stabilizing microtubule binding and force transmission during chromosome segregation.

The paper investigates the phosphorylation-dependent Ska-Ndc80 interaction and its role in microtubule tracking and force-coupling during chromosome segregation.

This study shows CENP-E and CENP-F recruit to kinetochores via distinct BubR1 and Bub1 interactions, highlighting paralog divergence in kinetochore function.