Katja Wassmann

This study shows Set is essential for chromosome alignment and Cohesin cleavage in oocyte meiosis, functioning through Aurora B regulation and chromatin environment modulation, independent of PP2A-B56 interaction.

The paper uses low-input proteomics to compare proteome and phosphoproteome changes in wild-type and separase-deficient mouse oocytes, revealing specific alterations in chromosome-associated proteins.

This study investigates separase inhibition and cohesin protection in oocytes, finding that cohesin is not protected early in meiosis I and at metaphase II arrest, and that kinetochore individualization in meiosis I is required for cohesin cleavage in meiosis II.