Restoring the Multiple Sclerosis Associated Imbalance of Gut Indole Metabolites Promotes Remyelination and Suppresses Neuroinflammation
Larissa Jank, Saumitra Sen Singh, Judy J. Lee, Asmita Dhukhwa, Fatemeh Siavoshi, Deepika Joshi, Veronica Minney, Kanak Gupta, Sudeep Ghimire, Pragney Deme, Vinícius Andreoli Schoeps, Karthik Soman, Dimitrios C. Ladakis, Matthew D. Smith, Kamil Borkowski, , Pavan Bhargava
The paper shows that indole lactate (ILA), reduced in MS, restores gut microbiome metabolic balance, promoting remyelination and reducing neuroinflammation.
bioRxiv · Oct 27, 2024 · PreprintNeuroscience