Matthew D. Smith

The paper shows that IFNγ and proinflammatory cytokines activate astrocytes to express antigen-presenting machinery, supporting CD4+ T cell restimulation in vitro and in vivo.

This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.

The paper uses spatial transcriptomics to study meningeal inflammation in a mouse model, identifying inflammatory gene signatures in adjacent brain parenchyma and highlighting candidate pathways in grey matter pathology.

The paper shows that indole lactate (ILA), reduced in MS, restores gut microbiome metabolic balance, promoting remyelination and reducing neuroinflammation.

The paper shows that bryostatin-1, a PKC modulator, shifts microglia and CNS macrophages from pro-inflammatory to regenerative states, promoting remyelination and neuroprotection in MS.

The paper introduces PSERM scoring to predict antibody variant properties from deep sequencing data, showing it outperforms traditional methods in reproducibility and correlation with experimental measurements.

This study shows bile acid metabolism is altered in multiple sclerosis, and supplementation with tauroursodeoxycholic acid reduces neuroinflammation in animal models.

This study shows that inhibiting nSMase2 improves myelin quality by protecting oligodendrocytes during remyelination.

This study shows OPCs can cross-present antigen and mediate cytotoxicity in MS, suggesting they are co-opted by the immune system.