Author

Pavan Bhargava

Johns Hopkins UniversityORCID 0000-0002-7947-9418Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:metabolomics· 2 Organism:mouse· 2 Approach:experimental assay· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

Peter A. CalabresiiD· 5 shared Matthew D. SmithiD· 3 shared Sol KimiD· 3 shared Arthur Anthony Reyes· 2 shared Emmanuelle L. WaubantiD· 2 shared Kathryn C. FitzgeraldiD· 2 shared Larissa JankiD· 2 shared Ranjan DuttaiD· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersNeuroscience

Peter A. CalabresiORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Extracellular Vesicles from Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement, and Aging-related Pathway Dysregulation

Larissa Jank, Madathiparambil Kumaran Satheesh Kumar, Taekyung Ryu, Rohit Thapa, Olesia A. Gololobova, Timothy D. Niepokny, Peter A. Calabresi, Kenneth Whitaker Witwer, Ranjan Dutta, Chan Hyun Na, Pavan Bhargava

The paper analyzes extracellular vesicles from MS and control white matter to identify pathway dysregulation and cellular origin shifts associated with the disease.

bioRxiv · Jun 2, 2025 · PreprintNeuroscience

Spatial Transcriptomics of Meningeal Inflammation Reveals Inflammatory Gene Signatures in Adjacent Brain Parenchyma

Sachin P. Gadani, Saumitra Singh, Sol Kim, Jingwen Hu, Matthew D. Smith, Peter A. Calabresi, Pavan Bhargava

The paper uses spatial transcriptomics to study meningeal inflammation in a mouse model, identifying inflammatory gene signatures in adjacent brain parenchyma and highlighting candidate pathways in grey matter pathology.

eLife · Oct 30, 2024Peer-reviewedNeuroscience

Restoring the Multiple Sclerosis Associated Imbalance of Gut Indole Metabolites Promotes Remyelination and Suppresses Neuroinflammation

Larissa Jank, Saumitra Sen Singh, Judy J. Lee, Asmita Dhukhwa, Fatemeh Siavoshi, Deepika Joshi, Veronica Minney, Kanak Gupta, Sudeep Ghimire, Pragney Deme, Vinícius Andreoli Schoeps, Karthik Soman, Dimitrios C. Ladakis, Matthew D. Smith, Kamil Borkowski, , Pavan Bhargava

The paper shows that indole lactate (ILA), reduced in MS, restores gut microbiome metabolic balance, promoting remyelination and reducing neuroinflammation.

bioRxiv · Oct 27, 2024 · PreprintNeuroscience

Imaging meningeal inflammation in CNS autoimmunity identifies a therapeutic role for BTK inhibition

Pavan Bhargava, Sol Kim, Arthur Anthony Reyes, Roland Grenningloh, Ursula Boschert, Martina Absinta, Carlos A. Pardo, Peter C.M. van Zijl, Jiangyang Zhang, Peter A. Calabresi

This study uses MRI to identify meningeal inflammation in a mouse model of multiple sclerosis and shows that BTK inhibition reduces inflammation.

Brain · Feb 8, 2021Peer-reviewedNeuroscience

Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation

Pavan Bhargava, Matthew D. Smith, Leah Mische, Emily Harrington, Kathryn C. Fitzgerald, Kyle A. Martin, Sol Kim, Arthur Anthony Reyes, Jaime Gonzalez Cardona, Christina M. Volsko, Ajai K. Tripathi, Sonal Singh, Kesava Varanasi, Hannah‐Noelle Lord, Keya R Meyers, , Peter A. Calabresi

This study shows bile acid metabolism is altered in multiple sclerosis, and supplementation with tauroursodeoxycholic acid reduces neuroinflammation in animal models.

Journal of Clinical Investigation · Mar 17, 2020Peer-reviewedNeuroscience