Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early-Onset Colorectal Cancer
Nicole C. Huning, Munir H. Buhaya, Victor Nguyen, Afeefah Khazi-Syed, Haider Ali, Adil R. Khan, Angela Fan, Robert C. Fisher, Zhikai Chi, Indu Raman, Guangchun Chen, Chengsong Zhu, Mengxi Yu, Andrew R. Jamieson, Sara Roccabianca, , Jacopo Ferruzzi
This study identifies biomechanical stiffening and fibrotic remodeling as hallmarks of early-onset colorectal cancer, showing their role in tumor initiation.
Advanced Science · Dec 1, 2025Peer-reviewedBioengineering