Zhikai Chi

The paper introduces STORM, a method to identify recurrent spatial motifs in colorectal cancer without cell-type labels, finding a fibroblast barrier linked to immune exclusion and prognosis.

This study investigates how inflammatory fibroblasts in ulcerative colitis and colitis-associated cancer contribute to disease progression through senescence and epigenetic memory.

This study introduces ReMiTT, a computational method to identify T cell migration trails in spatial transcriptomics data, revealing chemokine trends and enriched pathways associated with T cell movement in tumors.

This study identifies biomechanical stiffening and fibrotic remodeling as hallmarks of early-onset colorectal cancer, showing their role in tumor initiation.

This paper identifies geometric and spatial patterns in pancreatic cancer that correlate with aggressive behavior and develops an AI tool to improve clinical evaluation and treatment planning.