Author

Victor Tse

The University of Texas Southwestern Medical CenterPrimary ORCID profile (0009-0001-2072-591X · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Victor TseiD1 paper · University of California, Santa Cruz

Biology Disciplines

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Biochemistry· 2 Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Cristina R. Hofman· 2 shared David R. CoreyiD· 2 shared Guillermo Chacaltana· 2 shared Jeremy R. SanfordiD· 2 shared Jiaxin HuiD· 2 shared Martin E GutierreziD· 2 shared Michael D. StoneiD· 2 shared Alex J. Fay· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

Cristina R. Hofman

Mutual co-authors in cluster

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4 papers

Recent·Most cited

A novel splice site variant in DEGS1 leads to aberrant splicing and loss of DEGS1 enzyme activity, a VUS resolved

Holly C. Beale, Victor Tse, J.Y. Lee, Jon Akutagawa, Yusuph Mavura, Brandon Saint-John, Allison R. Cheney, Dennis Mulligan, Guillermo Chacaltana, Martin E Gutierrez, Jessica Tenney, Joseph T.C. Shieh, Pierre‐Marie Martin, Tiffany Yip, Uğur Hodoğlugil, , Anne Michele Slavotinek

The paper identifies a pathogenic splice site variant in DEGS1 causing aberrant splicing and loss of enzyme activity in individuals with HLD18.

Human Genetics · May 6, 2026Peer-reviewedGenetic & Genomic Medicine

Nuclear Argonaute:miRNA complexes recognize target sequences within chromatin and silence gene expression

Cristina R. Hofman, Jiaxin Hu, Rut Bryl, Victor Tse, David R. Corey

This study identifies nuclear miRNA:Argonaute complexes and their chromatin-associated RNA targets, showing miRNA-mediated gene silencing occurs in both nucleus and cytoplasm.

bioRxiv · May 8, 2025 · PreprintBiochemistry

Small molecule inhibition of CPSF3 impacts R-loop distribution

Cristina R. Hofman, Victor Tse, Jiaxin Hu, David R. Corey

The paper tests the effect of CPSF3 inhibitors YT-II-100 and JTE-607 on R-loop formation, finding global increases but no effect on specific R-loop positive control genes.

bioRxiv · May 7, 2025 · PreprintBiochemistry

Rescue of blood coagulation Factor VIII exon-16 mis-splicing by antisense oligonucleotides

Victor Tse, Guillermo Chacaltana, Martin E Gutierrez, Nicholas M. Forino, Arcelia Gonzalez Jimenez, Hanzhang Tao, H. Phong, Catherine Oh, Priyanka Chary, Isabel Quesada, Antonia Hamrick, Sophie Hyesuk Lee, Michael D. Stone, Jeremy R. Sanford

The paper identifies a three-way junction structure in intron 15 that affects F8 pre-mRNA splicing and shows that antisense oligonucleotides targeting this structure can rescue splicing defects in Hemophilia A.

bioRxiv · Mar 31, 2023 · PreprintMolecular Biology