STARD3 coordinates Endoplasmic Reticulum-late endosome/lysosome contacts and organelle positioning through a GSK3-regulated phosphorylation switch
Julie Eichler, Corinne Wendling, Sophie Huver, Mehdi Zouiouich, Victor Hanss, Anna Cardinal, Victoria Fimbel, Catherine Birck, Alastair G. McEwen, Céline Knorr, Catherine Fromental-Ramain, Maxime Boutry, Marie‐Pierre Chenard, Guillaume Drin, Catherine Tomasetto, Fabien Alpy
This study identifies GSK3 as the kinase responsible for phosphorylating STARD3, which regulates ER-LE/Lys contacts and endosome positioning through a phosphorylation switch.
The EMBO Journal · Feb 25, 2026Peer-reviewedCell Biology