Author

Alastair G. McEwen

Centre National de la Recherche ScientifiqueORCID 0000-0003-4484-3512Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Cousido-SiahiD· 2 shared Camille KostmanniD· 2 shared Gergő GógliD· 2 shared Gilles TravéiD· 2 shared Pascal Eberling· 2 shared ALBERTO D. PODJARNYiD· 1 shared Anna BonhoureiD· 1 shared Anna CardinaliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

A. Cousido-SiahORCID

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3 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedOct 31, 2026

Structural analysis of HERC2/UBE3A and HERC2/DOCK10 complexes provides new insights into the molecular basis of Angelman, Angelman-like and Dup15q Syndromes

Auguste Demenge, JiaWen Lim, Arpoudamarie Roc…·Gilles Travé

The paper analyzes the structural and functional interactions of HERC2/UBE3A and HERC2/DOCK10 complexes to understand their role in Angelman and Dup15q Syndromes.

DOI 10.1038/s41467-026-78412-0

humanstructural biology

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Cell BiologyThe EMBO JournalPeer-reviewedFeb 25, 2026

STARD3 coordinates Endoplasmic Reticulum-late endosome/lysosome contacts and organelle positioning through a GSK3-regulated phosphorylation switch

Julie Eichler, Corinne Wendling, Sophie Huver…·Fabien Alpy

This study identifies GSK3 as the kinase responsible for phosphorylating STARD3, which regulates ER-LE/Lys contacts and endosome positioning through a phosphorylation switch.

4 citationstop 1%

humanproteomics

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Systems BiologyJournal of the American Chemical SocietyPeer-reviewedMar 25, 2025

The Holdup Multiplex, an assay for high-throughput measurement of protein-ligand affinity constants using a mass-spectrometry readout

François Delalande, Søren Østergaard, Gergő Gógl…·Élodie Monsellier

The paper introduces a high-throughput mass-spectrometry-based assay to measure protein-ligand affinity constants, demonstrating its application to 14-3-3 isoforms and phosphopeptides.

20 citations

humanproteomics

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