Mehdi Zouiouich

The paper identifies cholesterol esterification as a mechanism that creates switch-like regulation of the INSIG/SCAP/SREBP2 pathway through ER membrane phase transitions.

This study identifies MOSPD2-STARD3 as a functional unit regulating late endosome/lysosome dynamics and cholesterol homeostasis through selective interaction at ER contact sites.

This study identifies GSK3 as the kinase responsible for phosphorylating STARD3, which regulates ER-LE/Lys contacts and endosome positioning through a phosphorylation switch.

The paper shows that the CE/TG ratio determines lipid droplet size and phase behavior, influencing their function and disease relevance.

This study identifies ORP5 as a key regulator of phosphatidic acid partitioning between triacylglycerol and cardiolipin synthesis at MAM-LD junctions, showing its role in balancing lipid metabolism and mitochondrial health.

The paper identifies steric repulsion as a mechanism regulating ER-to-LD protein movement, showing high-affinity proteins exclude lower-affinity ones during adipocyte differentiation.

This study shows that seipin regulates CAV1 trafficking and organelle interactions by controlling lipid metabolism and membrane order, impacting cellular homeostasis and metabolic disorders.