Author

Victoria G. Donovan

Dana-Farber Cancer Institute

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander C.-Y. Tsai· 1 shared Christian GegeiD· 1 shared Daniel P. CahilliD· 1 shared Daniel VittiD· 1 shared Diana D. ShiiD· 1 shared Dorothy M. Junginger· 1 shared Duane Nash· 1 shared Eleanor G. Kaplan· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alexander C.-Y. Tsai

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintApr 17, 2026

KDM6 Enzymes are the Mechanistic Targets of Mutant IDH that Dictate Replication Stress Sensitivity

Alexander C.-Y. Tsai, Mathew D. Lin, Vineshkumar Thidil Puliyappadamba…·Diana D. Shi

This study identifies KDM6 enzymes as targets of R2HG from mutant IDH, linking them to replication stress sensitivity in gliomas and introduces a DHODH inhibitor, GLIO-1, with potential clinical applications.

DOI 10.64898/2026.04.14.715350

humanproteomics

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