KDM6 Enzymes are the Mechanistic Targets of Mutant IDH that Dictate Replication Stress Sensitivity
Alexander C.-Y. Tsai, Mathew D. Lin, Vineshkumar Thidil Puliyappadamba…·Diana D. Shi
This study identifies KDM6 enzymes as targets of R2HG from mutant IDH, linking them to replication stress sensitivity in gliomas and introduces a DHODH inhibitor, GLIO-1, with potential clinical applications.