Cotranslational assembly confers specificity for in vivo target heterodimerization of paralogous H2B-like TAF12 proteins in the human fungal pathogen Candida albicans
Vidhi Bhardwaj, Selene K. Swanson, Laurence A. Florens, Michael P. Washburn, Jerry L. Workman, Krishnamurthy Natarajan
The paper identifies TFIID and SAGA complex subunits in C. albicans and shows that TAF12 paralogs form heterodimers through cotranslational assembly, ensuring specificity and stability of histone-like complexes.
bioRxiv · Jun 23, 2025 · PreprintGenetics