Jerry L. Workman

The paper uses an integrative approach to model the structure of an IDR-driven HDAC2 complex, revealing interactions not captured by AlphaFold alone.

The paper builds structural models of HDAC1/2-containing chromatin remodeling complexes using XL-MS and integrative modeling, revealing how the CTD IDR of HDAC1 folds into alpha helices.

The paper identifies TFIID and SAGA complex subunits in C. albicans and shows that TAF12 paralogs form heterodimers through cotranslational assembly, ensuring specificity and stability of histone-like complexes.

The paper investigates the role of the SAGA core module during Drosophila oogenesis and finds it is genetically essential despite the enzymatic modules being dispensable.

The paper introduces SCAP, a method combining affinity purification, live cell imaging, and cross-linking mass spectrometry to build integrative structural models of protein complexes.

This study identifies H3pT11 phosphorylation by Sch9 and CK2 as a regulator of lifespan through its role in nutritional stress response.