Alternative cGAS signaling promotes Herpes simplex encephalitis
Liraz Shmuel-Galia, Zhaozhao Jiang, Laurel Stine, Sara E. Cahill, Sze‐Ling Ng, Ruth Wilson, Richard K. Kandasamy, Evelyn A. Kurt‐Jones, Joshi M. Ramanjulu, John Bertin, Viera Kasparcova, G. Scott Pesiridis, Katherine A. Fitzgerald, Fiachra Humphries
This study identifies an alternative cGAS signaling pathway independent of cGAMP that promotes neutrophil recruitment and viral dissemination in herpes simplex encephalitis.
Proceedings of the National Academy of Sciences · May 27, 2025Peer-reviewedImmunology