Fiachra Humphries

This study identifies MARCO as a decoy LPS sensor regulated by non-canonical TLR signaling, which restricts inflammasome activation and prevents excessive inflammation.

This study develops a high-throughput platform using human cerebral organoids to screen for compounds that reverse HSV-1-induced neuroinflammation biomarkers associated with Alzheimer's disease.

This study identifies an alternative cGAS signaling pathway independent of cGAMP that promotes neutrophil recruitment and viral dissemination in herpes simplex encephalitis.

The paper identifies lysosomal TIR-1/SARM1 as a sensor for oxidative stress induced by pathogenic bacteria, activating intestinal immunity in C. elegans.