PathologybioRxivPreprint
ApoE4 Promotes Thrombosis via Endothelial Cell ApoER2 and PP2A Activation
Yike Sun, Anastasia Sacharidou, Kenian Chen…·Philip W. Shaul
This study identifies APOE4 as a risk factor for thrombosis by promoting vWF secretion through ApoER2 and PP2A activation in endothelial cells, leading to increased thrombosis in mice and human veins.
DOI 10.64898/2026.08.17.745317