DNA2 and MSH2 activity collectively mediate chemically stabilized G4 for efficient telomere replication
Anthony Fernandez, Tingting Zhou, Robert Steven Esworthy, Changxian Shen, Helen Liu, Jessica D. Hess, Hang Yuan, Nian Liu, Guojun Shi, Mian Zhou, Settapong T Kosiyatrakul, Vikas Gaur, Joshua A. Sommers, Winfried Edelmann, Guo‐Min Li, , Binghui Shen
The paper shows DNA2 and MSH2 work together to remove G4 structures at telomeres, preventing replication issues and telomere instability.
bioRxiv · Apr 4, 2025 · PreprintMolecular Biology