Author

Hang Yuan

City Of Hope National Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Assay:long-read sequencing· 1 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

Binghui SheniD· 3 shared Changxian SheniD· 2 shared Jessica D. HessiD· 2 shared Li ZhengiD· 2 shared Mian ZhouiD· 2 shared Nian LiuiD· 2 shared Xinyu PeiiD· 2 shared Yu ZhouiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

Binghui ShenORCID

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Author profile →

3 papers

Recent·Most cited

Oncometabolite fumarate impairs ATR-CHK1 signaling by succinating RPA1 in Fumarate Hydratase-deficient renal cell carcinoma cells

Nian Liu, Changxian Shen, Tingting Zhou, Yu Zhou, Hang Yuan, Hongjie Bi, Yingying Wang, Xinyu Pei, Rui Jun Su, Vijay Trisal, Li Zheng, Yihui H. Shi, Binghui Shen

This study shows fumarate impairs ATR-CHK1 signaling by succinating RPA1, leading to defective DNA repair and cell cycle control in FH-dRCC.

Cancer & Metabolism · Apr 28, 2026Peer-reviewedCancer Biology

DNA replication errors drive genome-wide small inverted triplication dynamics

Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen

The paper identifies DNA replication errors as a source of small inverted triplication (SIT) structural variants in yeast, showing their formation mechanism and characteristics.

Advanced Science · Apr 7, 2026Peer-reviewedGenetics

DNA2 and MSH2 activity collectively mediate chemically stabilized G4 for efficient telomere replication

Anthony Fernandez, Tingting Zhou, Robert Steven Esworthy, Changxian Shen, Helen Liu, Jessica D. Hess, Hang Yuan, Nian Liu, Guojun Shi, Mian Zhou, Settapong T Kosiyatrakul, Vikas Gaur, Joshua A. Sommers, Winfried Edelmann, Guo‐Min Li, , Binghui Shen

The paper shows DNA2 and MSH2 work together to remove G4 structures at telomeres, preventing replication issues and telomere instability.

bioRxiv · Apr 4, 2025 · PreprintMolecular Biology