Author

Changxian Shen

City Of Hope National Medical CenterORCID 0000-0002-7668-7166Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:DNA methylation· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Binghui SheniD· 2 shared Hang Yuan· 2 shared Nian LiuiD· 2 shared Anthony FernandeziD· 1 shared Barbara BedogniiD· 1 shared Barbra S. MilleriD· 1 shared Caleb Araujo· 1 shared Carl L. Schildkraut· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Binghui ShenORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Oncometabolite fumarate impairs ATR-CHK1 signaling by succinating RPA1 in Fumarate Hydratase-deficient renal cell carcinoma cells

Nian Liu, Changxian Shen, Tingting Zhou, Yu Zhou, Hang Yuan, Hongjie Bi, Yingying Wang, Xinyu Pei, Rui Jun Su, Vijay Trisal, Li Zheng, Yihui H. Shi, Binghui Shen

This study shows fumarate impairs ATR-CHK1 signaling by succinating RPA1, leading to defective DNA repair and cell cycle control in FH-dRCC.

Cancer & Metabolism · Apr 28, 2026Peer-reviewedCancer Biology

Targeting matrix metalloproteinase-14 disrupts DNA repair and reduces viability in adrenocortical carcinoma

Changxian Shen, Liudmila V. Popova, Daniel M. Chopyk, Lindsey Hartshorn, Zhongguang Li, Yaoling Shu, Caleb Araujo, Shivam Priya, Varsha Thakur, John E. Phay, Barbra S. Miller, Barbara Bedogni, Haichang Li, Priya H. Dedhia

This study shows MMP-14 is critical for ACC cell survival and DNA repair, and its inhibition reduces viability and impairs repair mechanisms.

bioRxiv · Jan 7, 2026 · PreprintCancer Biology

DNA2 and MSH2 activity collectively mediate chemically stabilized G4 for efficient telomere replication

Anthony Fernandez, Tingting Zhou, Robert Steven Esworthy, Changxian Shen, Helen Liu, Jessica D. Hess, Hang Yuan, Nian Liu, Guojun Shi, Mian Zhou, Settapong T Kosiyatrakul, Vikas Gaur, Joshua A. Sommers, Winfried Edelmann, Guo‐Min Li, , Binghui Shen

The paper shows DNA2 and MSH2 work together to remove G4 structures at telomeres, preventing replication issues and telomere instability.

bioRxiv · Apr 4, 2025 · PreprintMolecular Biology