Author

Nian Liu

City Of Hope National Medical CenterORCID 0000-0001-9393-239XUnclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Nian Liu2 papers · Center for Life Sciences

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Assay:imaging· 1

Frequent Co-Authors

Binghui SheniD· 2 shared Changxian SheniD· 2 shared Hang Yuan· 2 shared Anthony FernandeziD· 1 shared Carl L. Schildkraut· 1 shared Delong ZhangiD· 1 shared Dong ZhangiD· 1 shared Guo‐Min LiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Binghui ShenORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintJul 7, 2026

Clinically derived micro- and nanoplastics uptake drives spatiotemporally confined metabolic stress revealed by bond-selective imaging

Jingyuan Li, Nian Liu, Delong Zhang, Hyeon Jeong Lee

The paper uses bond-selective imaging to show that MP/NP-induced metabolic stress occurs during uptake, not long-term retention, and is mitigated by phospholipid coating.

DOI 10.64898/2026.07.02.735952

imagingmicroscopy & imaging analysis

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Cancer BiologyCancer & MetabolismPeer-reviewedApr 28, 2026

Oncometabolite fumarate impairs ATR-CHK1 signaling by succinating RPA1 in Fumarate Hydratase-deficient renal cell carcinoma cells

Nian Liu, Changxian Shen, Tingting Zhou…·Binghui Shen

This study shows fumarate impairs ATR-CHK1 signaling by succinating RPA1, leading to defective DNA repair and cell cycle control in FH-dRCC.

DOI 10.1186/s40170-026-00435-4

humanproteomics

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Molecular BiologybioRxivPreprintApr 4, 2025

DNA2 and MSH2 activity collectively mediate chemically stabilized G4 for efficient telomere replication

Anthony Fernandez, Tingting Zhou, Robert Steven Esworthy…·Binghui Shen

The paper shows DNA2 and MSH2 work together to remove G4 structures at telomeres, preventing replication issues and telomere instability.

DOI 10.1101/2025.04.04.647332

humanDNA methylation

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