Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice
Rodrigo Manuel Paz, Michael Ryan, Pamela F. Marcott, Allison E. Girasole, Joe Faryean, Vincent Duong, Sadhana Sridhar, Alexandra Nelson
This study shows that repeated levodopa treatment in Parkinsonian mice leads to striatal adaptations, specifically enhanced glutamatergic synapses on D1-MSNs and reduced D2R sensitivity, which contribute to worsening dyskinesia.
bioRxiv · May 16, 2025 · PreprintNeuroscience