Sadhana Sridhar

This study shows aging reduces functional connectivity in mouse V1 and CA1 regions, affecting synchrony in specific frequency bands without impairing single-neuron activity.

This study develops a mouse model of Parkinson's disease with impulse control disorder and shows that inhibiting indirect pathway neurons exacerbates abnormal decision-making.

This study shows that hypermyelination in FusOLcKO mice enhances hippocampal neuronal activity detection but disrupts cortical network communication.

This study shows that repeated levodopa treatment in Parkinsonian mice leads to striatal adaptations, specifically enhanced glutamatergic synapses on D1-MSNs and reduced D2R sensitivity, which contribute to worsening dyskinesia.

This study investigates how striatal lateral inhibition affects action selection in a mouse model of levodopa-induced dyskinesia, finding that altered inhibition contributes to involuntary movements.

This study evaluates hTau.P301S mice for PSP-like features, finding motor and eye movement impairments linked to Tau pathology.