Michael Ryan

This study shows that repeated levodopa treatment in Parkinsonian mice leads to striatal adaptations, specifically enhanced glutamatergic synapses on D1-MSNs and reduced D2R sensitivity, which contribute to worsening dyskinesia.

The paper investigates how levodopa-induced dyskinesia is linked to increased activity in specific striatal direct pathway medium spiny neurons, driven by dopamine and excitatory inputs.

The paper introduces a method for chronic, simultaneous neural recordings from multiple brain areas in mice, enabling long-term and flexible monitoring of neural activity during behavior.