The paper identifies metabolomic and lipidomic associations with depressive symptoms in the REGARDS study, finding significant longitudinal links between certain lipids and depressive symptoms, with sex-specific differences.

medRxiv · Aug 12, 2026 · PreprintGenetic & Genomic Medicine

Improving performance of polygenic risk scores for hypertension across two ancestry groups.

Marguerite R. Irvin, Vinodh Srinivasasainagendra, Nicole D. Armstrong, Amit Patki, Ulrich Broeckel, Zhe Wang, Leslie A. Lange, Nita A. Limdi, Alicia Huerta‐Chagoya, Joohyun Kim, Maggie C.Y. Ng, Josep Maria Mercader, Hemant K. Tiwari

This paper compares two Bayesian methods for polygenic risk scores (PRS) for hypertension across two ancestry groups, finding improved performance with updated LD panels and functional annotations, but not equitable results between groups.

PLoS ONE · Jul 24, 2026Peer-reviewedGenetic & Genomic Medicine

Ancestry Calibration of Polygenic Risk Scores Improves Risk Stratification and Effect Estimation in African American Adults

Luciana B. Vargas, Mariah Meyer, Iain R. Konigsberg, Aastha Kakar, Patrick M. Carry, Yun Li, Alana C Jones, Hemant K. Tiwari, Vinodh Srinivasasainagendra, Nicole D. Armstrong, Eimear E. Kenny, Bogdan Paşaniuc, Marguerite R. Irvin, Michael H. Cho, Maggie A. Stanislawski, , Ethan M. Lange

This study calibrates polygenic risk scores (PRS) for African American adults based on genetic ancestry, improving risk stratification and effect estimation for type 2 diabetes and height.

medRxiv · Jun 18, 2025 · PreprintGenetic & Genomic Medicine

Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus

Soo Heon Kwak, Ryan B. Hernandez-Cancela, DANIEL A. DICORPO, David E. Condon, Jordi Merino, Peitao Wu, Jennifer A. Brody, Jie Yao, Xiuqing Guo, Fariba Ahmadizar, Mariah Meyer, Murat Sincan, Josep Maria Mercader, Sujin Lee, Jeffrey Haessler, , James B. Meigs

This paper conducts a multi-ancestry time-to-event GWAS to identify genetic variants associated with incident cardiovascular disease in people with type 2 diabetes, finding three novel loci and confirming known CAD variants.

Diabetes Care · Apr 23, 2024Peer-reviewedGenetic & Genomic Medicine

Alpha globin gene copy number and incident ischemic stroke risk among Black Americans

Amy Parker Ruhl, Neal O. Jeffries, Yang Yu, Steven Brooks, Rakhi P P. Naik, Lydia H. Pecker, Bryan T. Mott, Cheryl Ann Winkler, Nicole D. Armstrong, Neil A. Zakai, Orlando M. Gutiérrez, Suzanne E. Judd, Virginia J. Howard, George Howard, Marguerite R. Irvin, , Hans Christian Ackerman

This study examines the association between alpha globin gene copy number and ischemic stroke risk in Black Americans, finding no significant association.

Frontiers in Stroke · Jun 15, 2023Peer-reviewedGenetic & Genomic Medicine

Validation of a Trans-Ancestry Polygenic Risk Score for Type 2 Diabetes in Diverse Populations

Tian Ge, Marguerite R. Irvin, Amit Patki, Vinodh Srinivasasainagendra, Kuang Lin, Hemant K. Tiwari, Nicole D. Armstrong, Barbara Benoit, Chia‐Yen Chen, Karmel W. Choi, James J. Cimino, Brittney H. Davis, Ozan Dikilitas, Bethany Etheridge, Yen‐Chen Anne Feng, , Elizabeth W. Karlson

This paper develops a trans-ancestry polygenic risk score for type 2 diabetes and validates it across diverse populations to improve equitable risk prediction.

Genome Medicine · Jun 28, 2022Peer-reviewedGenetic & Genomic Medicine