BiochemistryCommunications ChemistryPeer-reviewed
Revisiting p53:Sirt1 interaction in the light of controlling p53 acetylation levels
Vishnupriya Pandey, Frank Hause, Claudio Iacobucci…·Andrea Sinz
This study presents the first structural model of the full-length p53:Sirt1 complex, showing Sirt1 selectively deacetylates p53 at K582 and binds acetylated p53 with a 1:1 stoichiometry.
DOI 10.1038/s42004-026-02127-y