Author

W. Carver

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

C. Gao· 3 shared T. Cui· 3 shared V. Nguyen· 3 shared W. Tan· 3 shared X. Cao· 3 shared Y. Tian· 3 shared Y. Zhang· 3 shared D. Fan· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMicrobiology

C. Gao

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice

X. Cao, V. Nguyen, J. Tsai, C. Gao, Y. Tian, Y. Zhang, W. Carver, H. Kiaris, T. Cui, W. Tan

This study shows that the SARS-CoV-2 Spike protein causes long-term mitochondrial gene suppression, cardiac fibrosis, and reduced myocardial contractility in obese mice.

bioRxiv · Jan 5, 2023Microbiology

The Spike protein of SARS-CoV-2 impairs lipid metabolism and increases susceptibility to lipotoxicity: implication for a role of Nrf2

V. Nguyen, Y. Zhang, C. Gao, X. Cao, Y. Tian, W. Carver, H. Kiaris, T. Cui, W. Tan

This study shows that the SARS-CoV-2 Spike protein disrupts lipid metabolism and autophagy, increasing lipotoxicity via ferroptosis, which can be mitigated by Nrf2 inhibition.

bioRxiv · Apr 19, 2022Cell Biology

Effects of Emodin, a Plant-Derived Anthraquinone, on TGFβ1-Induced Cardiac Fibroblast Activation and Function

M. Azhar, W. Carver, E. Fix, C. Fix, D. Fan, M. Chakrabarti

This study shows emodin reduces TGFβ1-induced cardiac fibroblast activation and collagen accumulation by modulating key signaling pathways.

bioRxiv · Jan 7, 2021Cell Biology

Spike Protein of SARS-CoV-2 Activates Macrophages and Contributes to Induction of Acute Lung Inflammations in Mice

X. Cao, Y. Tian, V. Nguyen, Y. Zhang, C. Gao, R. Yin, W. Carver, D. Fan, H. Albrecht, T. Cui, W. Tan

This study shows that SARS-CoV-2 Spike protein activates macrophages and induces acute lung inflammation in mice.

bioRxiv · Dec 7, 2020 · PreprintPathology