R. Yin

Propofol overcome Tamoxifen resistance in breast cancer by modulating tumorogenesis, immune response and metabolism

This study shows Propofol overcomes Tamoxifen resistance in breast cancer by inducing cell cycle arrest, apoptosis, and altering gene expression related to cell cycle, immune response, and metabolism.

Mechanisms analysis for Formononetin counteracted-Osimertinib resistance in Non-small-cell lung cancer cells: from the insight into the gene transcriptional level

This study investigates how Formononetin reverses Osimertinib resistance in NSCLC cells by analyzing gene expression changes.

How persistent infection overcomes peripheral tolerance mechanisms to cause T cell-mediated autoimmune disease

The paper shows that persistent infections increase the likelihood of autoimmune T cell activation by exceeding a quorum threshold through molecular mimicry.

The Sequence Basis for Selectivity of Ephrin-B2 Ligand for Eph Receptors and Pathogenic Henipavirus G Glycoproteins

This paper identifies sequence changes in Ephrin-B2 that enhance its binding to henipavirus glycoproteins over Eph receptors, enabling the design of neutralizing decoy receptors.

Sustainable land management enhances ecological and economic multifunctionality under ambient and future climate

This study shows sustainable land management improves ecological and economic multifunctionality in agroecosystems, even under future climate conditions.

Single-cell transcriptome reveals the redifferentiation trajectories of the early stage of de novo shoot regeneration in Arabidopsis thaliana

The paper uses single-cell transcriptomics to study cell fate transitions during early de novo shoot regeneration in Arabidopsis, identifying redifferentiation trajectories and regulatory factors.

Single-cell Stereo-seq enables cell type-specific spatial transcriptome characterization in Arabidopsis leaves

This study introduces scStereo-seq, a method for single-cell spatial transcriptome profiling in Arabidopsis leaves, revealing cell type-specific spatial gene expression gradients and developmental trajectories.

Detection of Rapidly Accumulating Stress-Induced SUMO in Prostate Cancer Cells by a Fluorescent SUMO Biosensor

This study uses a fluorescent SUMO biosensor to show that prostate cancer cells have higher and reversible cytosolic SUMO enrichment under stress compared to normal cells.

Structural basis for recognition of two HLA-A2-restricted SARS-CoV-2 spike epitopes by public and private T cell receptors

The paper determines the structural basis for recognition of two SARS-CoV-2 spike epitopes by T cell receptors, revealing insights into epitope specificity and variation.

Structural and energetic profiling of SARS-CoV-2 antibody recognition and the impact of circulating variants

The paper maps antibody recognition of SARS-CoV-2 spike RBD using computational structural analysis and identifies antibodies effective against viral variants.

Spike Protein of SARS-CoV-2 Activates Macrophages and Contributes to Induction of Acute Lung Inflammations in Mice

This study shows that SARS-CoV-2 Spike protein activates macrophages and induces acute lung inflammation in mice.

CoV3D: A database and resource for high resolution coronavirus protein structures

CoV3D provides a database of coronavirus protein structures, including spike glycoprotein complexes, for vaccine and therapeutic design.

Climate change and intensive land use reduce soil animal biomass through dissimilar pathways

This study shows climate change and intensive land use reduce soil animal biomass through different pathways: climate change reduces body size, while land use decreases population size.

Up-regulation of autophagy by low concentration of salicylic acid delays methyl jasmonate-induced leaf senescence

O-GlcNAc transferase suppresses necroptosis and liver fibrosis

This study identifies O-GlcNAc transferase as a suppressor of hepatocyte necroptosis and liver fibrosis, using both human and mouse models.