Author

W. Grey

Primary ORCID profile (0000-0001-8209-5645 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

W. GreyiD1 paper · The Francis Crick Institute

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Bonnet· 2 shared J. Gribben· 2 shared A. Parsons· 1 shared A. Rio-Machin· 1 shared C. Christodoulidou· 1 shared C. Georgiou· 1 shared C. Heckman· 1 shared C. L. Lo Celso· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

D. Bonnet

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2 papers

Recent·Most cited

CKS1-dependent proteostatic regulation has dual roles combating acute myeloid leukemia whilst protecting normal hematopoiesis

W. Grey, A. Rio-Machin, P. Casado-Izquierdo, J. Miettinen, F. Copley, A. Parsons, C. Heckman, P. Cutillas, J. Gribben, J. Fitzgibbon, D. Bonnet

This study identifies CKS1-dependent proteostasis as a dual target for combating AML while protecting normal hematopoiesis through inhibition of SCFSKP2-CKS1.

bioRxiv · Dec 27, 2020 · PreprintCancer Biology

Dynamic regulation of hierarchical heterogeneity in Acute Myeloid Leukemia serves as a tumor immunoevasion mechanism

C. Pospori, W. Grey, S. Gonzalez-Anton, S. V. Gibson, C. Georgiou, F. Birch, G. Stevens, T. Williams, R. Khorshed, M. L. R. Haltalli, M.-N. Skoufou-Papoutsaki, K. Sloan, H. H. Encabo, J. Hopkins, C. Christodoulidou, , C. L. Lo Celso

The paper shows that hierarchical heterogeneity in AML cells, regulated by immune responses, contributes to disease progression through PDL1 upregulation and dynamic balance between proliferation and immunosuppression.

bioRxiv · Dec 21, 2020 · PreprintCancer Biology