P. Cutillas

SCD inhibition eradicates AML displaying high de novo fatty acid desaturation and synergizes with chemotherapy

SCD inhibition induces AML cell death and synergizes with chemotherapy to prolong survival in murine AML models.

Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double strand break repair in the G1 cell cycle phase.

This study identifies MAP7 and MAP7D1 as microtubule-associated proteins that facilitate DNA double-strand break repair during the G1 phase by interacting with repair proteins and modulating p53 phosphorylation and chromatin recruitment.

Extracellular matrix educates a tumor macrophage phenotype found in ovarian cancer metastasis

The paper shows that the tumor extracellular matrix educates macrophages to adopt a phenotype seen in ovarian cancer metastasis, affecting T cell function and immune regulation.

Proximity interactome of LC3B in normal growth conditions

The paper identifies 407 proteins interacting with LC3B in normal growth conditions using APEX2 proteomics, revealing novel interactors and expanding understanding of LC3B's roles beyond autophagy.

CKS1-dependent proteostatic regulation has dual roles combating acute myeloid leukemia whilst protecting normal hematopoiesis

This study identifies CKS1-dependent proteostasis as a dual target for combating AML while protecting normal hematopoiesis through inhibition of SCFSKP2-CKS1.

The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism

This study shows that IKKε, a breast cancer oncogene, reprograms mitochondrial function and serine metabolism independently of its canonical signaling role, promoting cancer cell proliferation.

Dynamic trafficking and turnover of Jam-C is essential for endothelial cell migration

The paper identifies Jam-C trafficking and ubiquitylation by CBL as essential for endothelial cell migration and junctional remodelling during angiogenesis.