Cell BiologybioRxiv
Computationally designed sensors for endogenous Ras activity reveal signaling effectors within oncogenic granules
J. Z. Zhang, W. H. Nguyen, N. Greenwood…·D. Baker
The paper develops computational sensors to measure endogenous Ras activity and identifies SAM68 as an effector enriched in oncogenic granules, showing its role in enhancing Ras activity and potential as a therapeutic target.
DOI 10.1038/s41587-023-02107-w