Author

J. Z. Zhang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Approach:deep learning· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:protein structure· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:electrophysiology· 1

Frequent Co-Authors

D. Baker· 4 shared D. J. Maly· 2 shared N. Greenwood· 2 shared S.-E. Ong· 2 shared A. Hand· 1 shared A. J. Borst· 1 shared A. Khmelinskaia· 1 shared A. Sarajovi· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersCancer Biology

D. Baker

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Single-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistance

J. Z. Zhang, S.-E. Ong, D. Baker, D. J. Maly

The paper uses single-cell signaling analysis to identify Major Vault Protein (MVP) as a mediator of RasG12C inhibitor resistance by facilitating Ras activation at different cellular compartments.

bioRxiv · Oct 2, 2023Cancer Biology

De novo designed Hsp70 activator dissolves intracellular condensates

J. Z. Zhang, N. Greenwood, J. Hernandez, J. T. Cuperus, B. Huang, B. D. Ryder, C. Queitsch, J. E. Gestwicki, D. Baker

The paper designs Hsp70 activators that dissolve intracellular condensates by modulating Hsp70 ATPase activity and promoting protein refolding.

bioRxiv · Sep 18, 2023 · PreprintBiochemistry

Computational design of non-porous, pH-responsive antibody nanoparticles

E. C. Yang, R. Divine, M. C. Miranda, A. J. Borst, W. Sheffler, J. Z. Zhang, J. Decarreau, A. Sarajovi, M. Abedi, N. Goldbach, M. Ahlrichs, C. Dobbins, A. Hand, S. Cheng, M. Lamb, , D. Baker

This paper designs pH-responsive antibody nanoparticles with three distinct protein components that disassemble at tunable pH levels, enabling targeted delivery of biologics.

bioRxiv · Apr 17, 2023Bioengineering

Computationally designed sensors for endogenous Ras activity reveal signaling effectors within oncogenic granules

J. Z. Zhang, W. H. Nguyen, N. Greenwood, J. C. Rose, S.-E. Ong, D. J. Maly, D. Baker

The paper develops computational sensors to measure endogenous Ras activity and identifies SAM68 as an effector enriched in oncogenic granules, showing its role in enhancing Ras activity and potential as a therapeutic target.

bioRxiv · Nov 22, 2022Cell Biology

A biophotoelectrochemical approach to unravelling the role of cyanobacterial cell structures in exoelectrogenesis

L. T. Wey, J. M. Lawrence, X. Chen, R. Clark, D. J. Lea-Smith, J. Z. Zhang, C. J. Howe

This study uses photoelectrochemistry to investigate electron transfer pathways in cyanobacteria, showing the periplasmic space's role in exoelectrogenesis and the contribution of type IV pili to electrode adherence.

bioRxiv · Apr 1, 2021Biochemistry