Author

D. J. Maly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 5 Approach:experimental assay· 5 Organism:human· 5 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

S.-E. Ong· 4 shared D. Baker· 2 shared H.-T. Lau· 2 shared J. Z. Zhang· 2 shared M. Golkowski· 2 shared A. Hiniker· 1 shared A. Lius· 1 shared A. Shoemaker· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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4 shared papersCancer Biology

S.-E. Ong

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Single-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistance

J. Z. Zhang, S.-E. Ong, D. Baker, D. J. Maly

The paper uses single-cell signaling analysis to identify Major Vault Protein (MVP) as a mediator of RasG12C inhibitor resistance by facilitating Ras activation at different cellular compartments.

bioRxiv · Oct 2, 2023Cancer Biology

A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

T. Uo, K. K. Ojo, C. C. Sprenger, K. S. Epilepsia, B. G. K. Perera, M. Damodarasamy, S. Sun, S. Kim, H. H. Hogan, M. A. Hulverson, R. Choi, G. R. Whitman, L. K. Barrett, S. A. Michaels, L. H. Xu, , S. R. Plymate

This paper evaluates a novel antiglycolytic compound, BKIDC-1553, showing selective growth inhibition of prostate cancer cells and safety for clinical trials.

bioRxiv · Jul 1, 2023Cancer Biology

Computationally designed sensors for endogenous Ras activity reveal signaling effectors within oncogenic granules

J. Z. Zhang, W. H. Nguyen, N. Greenwood, J. C. Rose, S.-E. Ong, D. J. Maly, D. Baker

The paper develops computational sensors to measure endogenous Ras activity and identifies SAM68 as an effector enriched in oncogenic granules, showing its role in enhancing Ras activity and potential as a therapeutic target.

bioRxiv · Nov 22, 2022Cell Biology

Profiling of the drug resistance of thousands of Src tyrosine kinase mutants uncovers a regulatory network that couples autoinhibition to catalytic domain dynamics

S. Chakraborty, E. Ahler, J. Simon, L. Fang, Z. Potter, K. Sitko, J. Stephany, M. Guttman, D. Fowler, D. J. Maly

bioRxiv · Dec 5, 2021 · PreprintBiochemistry

Multiplexed profiling of kinase interactomes quantifies cellular network plasticity

M. Golkowski, A. Lius, T. S. Sapre, H.-T. Lau, T. Moreno, D. J. Maly, S.-E. Ong

The paper introduces Ki-CCA, a method to map kinase PPIs across cancer cell lines, revealing network plasticity and identifying therapeutic targets.

bioRxiv · Sep 14, 2021 · PreprintBiochemistry

Kinome-centric pharmacoproteomics identifies signaling pathways underlying cellular responses to targeted cancer drugs

M. Golkowski, H.-T. Lau, M. Chan, H. Kenerson, V. N. Vidadala, A. Shoemaker, D. J. Maly, R. S. Yeung, T. S. Gujral, S.-E. Ong

The paper develops a kinome-centric pharmacoproteomics platform to identify signaling pathways and biomarkers predicting cancer drug responses and resistance in hepatocellular carcinoma.

bioRxiv · Nov 20, 2019Cancer Biology

Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival

P. C. Moore, J. Y. Qi, M. Thamsen, R. Ghosh, J. Peng, M. J. Gliedt, R. Meza-Acevedo, R. E. Warren, A. Hiniker, G. E. Kim, D. J. Maly, B. J. Backes, F. R. Papa, S. A. Oakes

This study shows that targeting the UPR components IRE1α and PERK can inhibit pancreatic neuroendocrine tumor growth by inducing apoptosis through reciprocal signaling.

bioRxiv · Sep 18, 2019Cancer Biology