Author

J. C. Rose

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

K. E. Yost· 2 shared K. L. Hung· 2 shared P. S. Mischel· 2 shared B. Daniel· 1 shared C. V. Duffy· 1 shared D. Baker· 1 shared D. J. Maly· 1 shared E. J. Curtis· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCancer Biology

K. E. Yost

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair

J. C. Rose, I. T.-L. Wang, B. Daniel, M. G. Jones, K. E. Yost, K. L. Hung, E. J. Curtis, P. S. Mischel, H. Chang

This study uses a CRISPR-based method to investigate ecDNA formation, showing efficient circularization and distinct repair pathways for ecDNA and chromosomal scars.

bioRxiv · Oct 22, 2023Cancer Biology

Computationally designed sensors for endogenous Ras activity reveal signaling effectors within oncogenic granules

J. Z. Zhang, W. H. Nguyen, N. Greenwood, J. C. Rose, S.-E. Ong, D. J. Maly, D. Baker

The paper develops computational sensors to measure endogenous Ras activity and identifies SAM68 as an effector enriched in oncogenic granules, showing its role in enhancing Ras activity and potential as a therapeutic target.

bioRxiv · Nov 22, 2022Cell Biology

EcDNA hubs drive cooperative intermolecular oncogene expression

K. L. Hung, K. E. Yost, L. Xie, S. Wu, J. T. Lange, C. V. Duffy, K. Kraft, J. Tang, Q. Shi, J. C. Rose, M. R. Corces, J. M. Granja, R. Li, U. Rajkumar, R. Tjian, , H. Y. Chang

The paper identifies ecDNA hubs as nuclear structures that drive cooperative oncogene expression through intermolecular enhancer-promoter interactions and shows BET inhibitors can disrupt these hubs and kill cancer cells.

bioRxiv · Nov 19, 2020Cancer Biology