S.-E. Ong

Mitochondrial Calcium Signaling Regulates Branched-Chain Amino Acid Catabolism in Fibrolamellar Carcinoma

This study shows that mitochondrial calcium signaling regulates branched-chain amino acid catabolism and the urea cycle in fibrolamellar carcinoma through transcriptional control of metabolic genes.

Single-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistance

The paper uses single-cell signaling analysis to identify Major Vault Protein (MVP) as a mediator of RasG12C inhibitor resistance by facilitating Ras activation at different cellular compartments.

Cellular RNA interacts with MAVS to promote antiviral signaling

The paper shows that cellular RNA interacts with MAVS to scaffold signaling proteins and promote antiviral signaling by facilitating IRF3 phosphorylation.

Computationally designed sensors for endogenous Ras activity reveal signaling effectors within oncogenic granules

The paper develops computational sensors to measure endogenous Ras activity and identifies SAM68 as an effector enriched in oncogenic granules, showing its role in enhancing Ras activity and potential as a therapeutic target.

Multiplexed profiling of kinase interactomes quantifies cellular network plasticity

The paper introduces Ki-CCA, a method to map kinase PPIs across cancer cell lines, revealing network plasticity and identifying therapeutic targets.

Kinome-centric pharmacoproteomics identifies signaling pathways underlying cellular responses to targeted cancer drugs

The paper develops a kinome-centric pharmacoproteomics platform to identify signaling pathways and biomarkers predicting cancer drug responses and resistance in hepatocellular carcinoma.

CCDC186 controls dense-core vesicle cargo sorting by exit

This study identifies CCDC186 as a regulator of DCV cargo sorting by exit, showing its role in retaining mature DCV cargos and removing non-DCV cargos post-TGN.