Author

W. M. Freeman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Physiology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. Isola· 2 shared M. Stout· 2 shared R. Sathiaseelan· 2 shared S. Ali Mondal· 2 shared S. Mann· 2 shared S. R. Ocanas· 2 shared A. R. Moore· 1 shared A. Rothman· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

J. Isola

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A single-cell atlas of the aging murine ovary

J. Isola, S. R. Ocanas, C. Hubbart, S. Ko, S. Ali Mondal, J. Hense, H. N. C. Carter, A. Schneider, S. Kovats, J. Alberola-Ila, W. M. Freeman, M. Stout

This study creates a single-cell RNA sequencing atlas of aging mouse ovaries, identifying immune cell expansion, collagenase pathway downregulation, and stress/fibrotic signaling in follicular cells.

bioRxiv · Apr 29, 2023 · PreprintCell Biology

17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice

S. Ali Mondal, R. Sathiaseelan, S. Mann, M. Kamal, W. Luo, T. Saccon, J. Isola, R. Peeler, T. Li, W. M. Freeman, B. Miller, M. Stout

This study shows that 17-E2 reduces liver fibrosis in male mice by decreasing collagen synthesis and increasing collagen degradation.

bioRxiv · Jun 16, 2022Physiology

The NOTCH3 Downstream Target HEYL Regulates Human Airway Epithelial Club Cell Differentiation

M. Bodas, B. Subramaniyan, A. R. Moore, J. P. Metcalf, S. R. Ocanas, W. M. Freeman, C. Georgescu, J. D. Wren, M. S. Walters

This study identifies HEYL as a downstream target of NOTCH3 that regulates human airway epithelial club cell differentiation through in vitro and in vivo analyses.

bioRxiv · Mar 10, 2021 · PreprintCell Biology

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

S. Mann, N. Hadad, M. Nelson, A. Rothman, R. Sathiaseelan, S. Ali-Mondal, M.-P. Agbaga, A. Unnikrishnan, S. Malayannan, J. Hawse, D. Huffmam, W. M. Freeman, M. B. Stout

This study shows 17α-estradiol improves metabolic parameters and slows aging in male mice and rats through estrogen receptor α, primarily acting in the liver and hypothalamus.

bioRxiv · Jun 2, 2020Physiology