Identification of Novel Allosteric Sites of SARS-CoV-2 Papain-Like Protease (PLpro) for the Development of COVID-19 Antivirals
J. C. Ferreira, K. Al Adem, S. Fadl, A. J. Villanueva, L. Alzyoud, M. A. Ghattas, W. M. Rabeh
This study identifies three potential allosteric sites on SARS-CoV-2 PLpro, evaluates their impact on proteolytic activity through alanine mutagenesis, and highlights Pockets 1 and 3 as promising targets for antiviral drug development.
bioRxiv · May 16, 2023Biochemistry