Author

J. C. Ferreira

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1

Frequent Co-Authors

W. M. Rabeh· 2 shared A. Cakir· 1 shared A. Elezaby· 1 shared A. G. O. Demir· 1 shared A. J. Lin· 1 shared A. J. Villanueva· 1 shared A. L. C. Darini· 1 shared A. Mardinoglu· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

W. M. Rabeh

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification of Novel Allosteric Sites of SARS-CoV-2 Papain-Like Protease (PLpro) for the Development of COVID-19 Antivirals

J. C. Ferreira, K. Al Adem, S. Fadl, A. J. Villanueva, L. Alzyoud, M. A. Ghattas, W. M. Rabeh

This study identifies three potential allosteric sites on SARS-CoV-2 PLpro, evaluates their impact on proteolytic activity through alanine mutagenesis, and highlights Pockets 1 and 3 as promising targets for antiviral drug development.

bioRxiv · May 16, 2023Biochemistry

Cardiac Troponin I Directly Binds and Inhibits Mitochondrial ATP Synthase: a Noncanonical Role in the Post-Ischemic Heart

A. Elezaby, A. J. Lin, V. Vijayan, S. Pokhrel, L. R. Bechara, N. P. Ostberg, B. B. Queliconi, J. C. Campos, J. C. Ferreira, B. Haileselassie, D. Mochly-Rosen

This study identifies a noncanonical role of cardiac troponin I in inhibiting mitochondrial ATP synthase, showing that blocking this interaction reduces cardiac injury during ischemia.

bioRxiv · Feb 3, 2023Cell Biology

Hexokinase 1b is a novel target for non-small-cell lung cancer

Y. Yozgat, E. Karakoc, O. Sahin, S. Cimen, W. M. Rabeh, M. S. Aydin, A. Mardinoglu, I. Gursel, A. Cakir, O. Sensoy, E. M. Ozdemir, Y. Bayrak, M. Z. Gunluoglu, O. Saatci, J. Jabbar, , M. A. Cevher

This study identifies HK1b as a novel therapeutic target in NSCLC by showing its role in glycolysis, tumor progression, and cisplatin resistance.

bioRxiv · Jun 27, 2022 · PreprintCancer Biology

Cannabidiol (CBD) repurposing as antibacterial: promising therapy of CBD plus polymyxin B against superbugs

N. Abichabki, L. V. Zacharias, N. C. Moreira, F. Bellissimo-Rodrigues, F. d. L. Moreira, J. R. d. L. Benzi, T. M. C. Ogasawara, J. C. Ferreira, L. R. L. Pereira, G. U. L. Braga, C. M. Ribeiro, F. R. Pavan, A. W. Zuardi, J. E. C. Hallak, J. A. d. S. Crippa, , L. N. Andrade

This study evaluates CBD's antibacterial activity and its combination with polymyxin B against multidrug-resistant bacteria, showing synergistic effects against resistant strains.

bioRxiv · Apr 12, 2021 · PreprintMicrobiology