Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer
B. Dong, J. Miao, Y. Wang, W. Luo, Z. Ji, H. Lai, M. Zhang, X. Cheng, J. Wang, Y. Fang, H. H. Zhu, C. W. Chua, L. Fan, Y. Zhu, J. Pan, , W. Q. Gao
The paper uses single-cell RNA sequencing to show neuroendocrine prostate cancer cells originate from luminal-like cells, not basal cells, and identifies associated gene signatures.
bioRxiv · May 12, 2020Cancer Biology