An integrated signaling threshold initiates IgG response towards virus-like immunogens
W. Wholey, A. R. Meyer, S.-T. Yoda, J. L. Mueller, R. Mathenge, B. Chackerian, J. Zikherman, W. Cheng
The paper identifies that a combination of surface antigen density and internal nucleic acids is sufficient to initiate strong antiviral IgG responses without T cell help or Toll-like receptor signaling.
bioRxiv · Jan 28, 2024Immunology