S.-T. Yoda

Minimal determinants for lifelong antiviral antibody responses in BALB/c mice from a single exposure to virus-like immunogens at low doses

This study shows that a single low-dose injection of virus-like immunogens induces lifelong neutralizing antibodies in mice, highlighting key determinants for durable antiviral immunity.

An integrated signaling threshold initiates IgG response towards virus-like immunogens

The paper identifies that a combination of surface antigen density and internal nucleic acids is sufficient to initiate strong antiviral IgG responses without T cell help or Toll-like receptor signaling.

Molecular basis for potent B cell responses to antigen displayed on particles of viral size

This study identifies the molecular mechanisms by which particulate antigens induce potent B cell responses, showing signal amplification and reduced proliferation thresholds independent of T cell help and BCR avidity.