Author

J. Zikherman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 7 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:clustering· 1

Frequent Co-Authors

J. L. Mueller· 5 shared J. F. Brooks· 4 shared R. Hiwa· 3 shared S.-T. Yoda· 3 shared W. Cheng· 3 shared A. R. Meyer· 2 shared B. Chackerian· 2 shared C. Tan· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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5 shared papersImmunology

J. L. Mueller

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8 papers

Recent·Most cited

An integrated signaling threshold initiates IgG response towards virus-like immunogens

W. Wholey, A. R. Meyer, S.-T. Yoda, J. L. Mueller, R. Mathenge, B. Chackerian, J. Zikherman, W. Cheng

The paper identifies that a combination of surface antigen density and internal nucleic acids is sufficient to initiate strong antiviral IgG responses without T cell help or Toll-like receptor signaling.

bioRxiv · Jan 28, 2024Immunology

Validation of a murine proteome-wide phage display library for the identification of autoantibody specificities

E. Rackaityte, I. Proekt, H. S. Miller, A. Ramesh, J. F. Brooks, A. F. Kung, C. Mandel-Brehm, D. Yu, C. Zamecnik, R. Bair, S. E. Vazquez, S. Sunshine, C. L. Abram, C. A. Lowell, G. Rizzuto, , J. L. DeRisi

This paper validates a murine proteome-wide PhIP-seq library to identify autoantibody specificities in autoimmune disease models.

bioRxiv · Apr 7, 2023Immunology

Minimal determinants for lifelong antiviral antibody responses in BALB/c mice from a single exposure to virus-like immunogens at low doses

W.-Y. Wholey, A. R. Meyer, S.-T. Yoda, B. Chackerian, J. Zikherman, W. Cheng

This study shows that a single low-dose injection of virus-like immunogens induces lifelong neutralizing antibodies in mice, highlighting key determinants for durable antiviral immunity.

bioRxiv · Feb 20, 2023Immunology

Molecular basis for potent B cell responses to antigen displayed on particles of viral size

J. F. Brooks, J. Riggs, J. L. Mueller, R. Mathenge, W.-Y. Wholey, S.-T. Yoda, V. Vykunta, W. Cheng, J. Zikherman

This study identifies the molecular mechanisms by which particulate antigens induce potent B cell responses, showing signal amplification and reduced proliferation thresholds independent of T cell help and BCR avidity.

bioRxiv · Feb 15, 2023 · PreprintImmunology

Regulation of layered T cell tolerance mechanisms by the NR4A family is essential to preserve immune homeostasis and suppress autoimmunity

R. Hiwa, H. V. Nielsen, J. L. Mueller, J. Zikherman

This study shows that NR4A family members are essential for multiple T cell tolerance mechanisms, preventing autoimmunity even when Tregs are intact.

bioRxiv · Apr 28, 2021Immunology

Negative feedback by NUR77/Nr4a1 restrains B cell clonal dominance during early T-dependent immune responses

J. F. Brooks, C. Tan, J. L. Mueller, K. Hibiya, R. Hiwa, J. Zikherman

This study shows that NUR77/Nr4a1 negatively regulates B cell clonal dominance in early T-dependent immune responses to maintain diversity in the germinal center niche.

bioRxiv · Dec 25, 2020Immunology

A negative feedback loop mediated by the NR4A family of nuclear hormone receptors restrains expansion of B cells that receive signal one in the absence of signal two

C. Tan, R. Hiwa, J. L. Mueller, V. Vykunta, K. Hibiya, M. Noviski, J. Huizar, J. F. Brooks, J. Garcia, C. Heyn, Z. Li, A. Marson, J. Zikherman

This study identifies a negative feedback loop involving NR4A receptors that limits B cell proliferation without T cell help and enhances antibody responses to T-independent antigens.

bioRxiv · Mar 31, 2020Immunology

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis

J. Ashouri, L.-Y. Hsu, S. Yu, D. Rychkov, Y. Chen, D. Chang, M. Sirota, E. Hansen, L. Lattanza, J. Zikherman, A. Weiss

The paper identifies arthritogenic CD4 T cells in murine and human autoimmune arthritis using Nur77 as a marker of TCR signaling.

bioRxiv · Mar 12, 2019Immunology